The importance of capillary density–stroke work mismatch for right ventricular adaptation to chronic pressure overload
نویسندگان
چکیده
منابع مشابه
Right atrial and ventricular adaptation to chronic right ventricular pressure overload.
BACKGROUND Increased mortality in patients with chronic pulmonary hypertension has been associated with elevated right atrial (RA) pressure. However, little is known about the effects of chronic right ventricular (RV) pressure overload on RA and RV dynamics or the adaptive response of the right atrium to maintain RV filling. METHODS AND RESULTS In 7 dogs, RA and RV pressure and volume (conduc...
متن کاملComplete reversibility of cat right ventricular chronic progressive pressure overload.
Chronic, progressive pressure overload of the cat right ventricle produces persistent, ongoing abnormalities of contractile, energetic, and biochemical function in vitro at a time when in vivo pump function is still normal. The present study tested the reversibility of the in vitro changes in this clinically relevant hypertrophy model. Fourteen sham-operated and 14 reversal cats were studied. A...
متن کاملRight Ventricular Dysfunction and Failure in Chronic Pressure Overload
Right ventricular (RV) dysfunction is the main cause of death in pulmonary arterial hypertension (PAH). Our understanding of the pathophysiology of RV dysfunction is limited but improving. Methods to better diagnose RV dysfunction earlier and treatments specifically designed to minimize or reverse the remodeling process are likely to improve outcomes. We review the current understanding of RV d...
متن کاملRight ventricular dysfunction persists following brief right ventricular pressure overload.
OBJECTIVE Acute pulmonary hypertension may cause right ventricular (RV) contractile failure. While it has been assumed that restoration of normal loading conditions after acute pulmonary hypertension is sufficient for complete recovery of RV function, this has not been rigorously examined. The purpose of this study was to test the hypothesis that acute RV pressure overload produces RV contracti...
متن کاملEarly improvement in left ventricular diastolic function after relief of chronic right ventricular pressure overload.
Chronic right ventricular pressure overload is associated with left ventricular diastolic dysfunction. Whether or not an abrupt reduction in pulmonary artery pressure in patients with chronic pulmonary hypertension results in early improvement of left ventricular diastolic function is unknown. To assess this, the Doppler indexes of left ventricular diastolic function and echocardiographic measu...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2017
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2017.05.102